NCHS Data Brief
Taking it slow under your doctor's guidance lets your body adapt, helps you both see how the medication works for you, and allows for any needed adjustments." If you experience significant side effects when you move up a dose, your doctor has options: Delay the dose increase: Your doctor may keep you on a lower dose for an extra four weeks to give your body more time to adjust before trying to move up again

Additional but rare side effects include: low blood sugar (hypoglycemia) feeling cold unusual muscle pain dizziness slow or irregular heart rate trouble breathing metallic taste changes to nails on fingers and toes Low b12 levels DRUG INTERACTIONS As with other medications, metformin can interact with alcohol and certain medications, including angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, corticosteroids, hormone replacement therapy and estrogens, oral contraceptives, carbonic anhydrase inhibitors, nifedipine, thiazides or furosemide and other diuretics, phenothiazines, phenytoin, nicotinic acid (niacin), multidrug and toxin extrusion inhibitors, sympathomimetics, calcium channel blockers, isoniazid (antibiotic for tuberculosis), insulin and glyburide or other medications for diabetes, and medications for thyroid disease
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